Do you know that one of the 4 patients with colorectal cancer is caused by hereditary factors?
Colorectal cancer, also known as colorectal cancer, is the top 3 cancer incidence in China. It is also the largest proportion of hereditary tumors. About 25% of colorectal cancer is caused by genetic factors. Because of the high incidence of hereditary colorectal cancer, the international community is very concerned about the hereditary colorectal cancer. The recommended guidelines for the diagnosis, screening and risk management of hereditary colorectal cancer have also been clearly pointed out in the --NCCN guidelines of the most authoritative international oncology clinical practice guideline.
The most common type of hereditary colorectal cancer:
1. Lynch syndrome (Lynch syndrome) is one of the most common hereditary colorectal cancer syndrome. Patients with Lynch's syndrome have increased risk of colorectal cancer, stomach cancer, and endometrial cancer, and the risk of colorectal cancer is up to 80%. Lynch's syndrome is accompanied by obvious family characteristics, and the age of the disease is ahead of time.
Lynch's syndrome is caused by a mutation in a gene family called MMR. MMR gene family members include MLH1/MSH6/PMS2 and many other genes. These genes play an important role in DNA mismatch repair, which can ensure that DNA accurately copy and transmit genetic information. If these mutations cause genetic dysfunction, DNA in the human body may become unstable. Some of the genome will make mistakes, leading to disease.
The United States National Comprehensive Cancer Network (NCCN) recommends that patients with colorectal cancer receive genetic testing of Lynch's syndrome. Similarly, the American Cancer Association (AJCC) suggests that all patients with colorectal cancer should have Lynch syndrome gene detection after admission. For those who are positive, their family members will also receive Lynch syndrome gene detection.
2., familial gonadal polyposis (FAP) is characterized by multiple polyps in the intestine. In colorectal, these polyps are at high risk of malignant transformation, even up to 90%. FAP is caused by a mutation in a gene called APC that causes its normal function to be unable to complete. The children of the hereditary mutation carrier have the same mutation with 50% of the probability, and the other direct relatives also have a high risk of carrying the same mutation.
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Enjoy the medicine launch of hereditary colorectal cancer gene detection, can be a one-time detection including APC / MMR family, ten with hereditary colorectal cancer is highly related genes, including various common hereditary colorectal cancer associated genes, and hereditary colorectal cancer risk assessment, risk control for the future, care for life.
Intended for
1) colorectal cancer patients: screening for genetic colorectal cancer, providing targeted treatment, and providing important information for relatives.
2) high risk population: familial colorectal cancer patients, relatives and other high-risk groups.
3) all the people who are concerned about the health of the intestines.
