If someone tells you &ldquo, the changes in intestinal activity may affect the human mood ” maybe you might think it's just a matter of night. However, although there is no direct evidence that there is such a link between gut and brain, Cell's recent research on the gut seems to make this hypothesis not so far away.

In the dense villus and wrinkles of the alimentary tract, there are countless tiny “ the household ” bacteria, fungi, and even parasites. Different groups of microorganisms divide the land in the vast space, build their own communities, and usually live in harmony with each other. Most of them depend on food residues in the gut, while they are &ldquo and &rdquo. They help us digest and absorb nutrition in food.

In fact, these microorganisms may play a pivotal role in many physiological activities related to the gut. — — for example, the synthesis of 5- serotonin (5-HT).

The new study found that the host microorganism interaction process between the intestinal endocrine cells (right) and sporulation bacteria (left) is critical for the biosynthesis of 5- serotonin.

Recently, California Institute of Technology biologist Elaine &middot, Elaine Y. Hsiao and others found that the existence of some microbes in the gut can have a profound impact on the synthesis of 5- serotonin. In a mouse model experiment, the researchers found that the content of 5- serotonin in the blood of the mice in the intestinal tract &ldquo and &rdquo was about 60%[1] lower than that in the normal mice.

In a subsequent survey, about 20 species of spore - producing bacteria were identified as the main “ suspected bacteria ” The researchers isolated sporulation bacteria from healthy mice and human intestines and injected them into the above “ sterile ” in mice, the concentration of 5- serotonin in intestinal and blood increased significantly. This also confirms their role in the metabolism of 5- hydroxytryptamine.

Why do these bacteria participate in the synthesis of 5- serotonin? At present, the scientists also did not get the exact conclusion a possible explanation is that the 5- secretion of serotonin can have an effect on the immune system, and ecology of the gut microbial communities of the regulation of — — so, these bacteria sporulation may not be the suspect, &rdquo & ldquo;; instead, they may also be in the discovery of bacteria after timely communication with the host, the thief alarm law-abiding citizens.

In addition, in the experiment of some interesting facts also allow researchers to see the potential value of this study: the metabolic process of sporulation colonies increased intestinal vitamin E (α -tocopherol) and the concentration of vitamin E deficiency is a part of the performance of patients with depression. In some clinical trials, vitamin E supplementation can relieve the depressive symptoms of the patient. Is there an association between such facts? Are the small eyes in the intestines that are not visible? Are they in their own unique way to participate in people's happiness and sorrow? Perhaps in the near future, people will be able to know the secret.

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I am not me, I am “ we are ”

Recommendations for the enjoyment of medical enjoyment: detection of intestinal flora and individualized drug use

Intestinal microflora — — second human genome

The number is 10 times the number of human cells

The number of genes is 100 times the number of human genes

90% of the disease can be traced to its health

80%-90%'s microbes are different from other people

99.9% of people can be identified by unique intestinal flora

The same drugs and doses do not necessarily apply to all patients of the same disease. The effects and side effects of different people after taking medicine are different.

By detecting the genotypes of intestinal microflora, we can judge the fast and slow metabolism of different drugs and guide the safe use of drugs.