The latest survey found that the incidence of genetic predisposing gene mutations in colorectal cancer was 10%, 7% higher than the traditional one. Investigators have called for more gene testing, which will not omit 7% of the risk population and improve the care after the treatment.

A study involving thousands of colorectal cancer patients reveals that about 10% of the patients carry a mutation that increases the risk of cancer, which is much higher than that of 3% previously known. The conclusions are published in the Journal of Clinical Oncology (abbreviated JCO) magazine. This study reflects the importance of genetic detection to predict genetic risk. — — not only helps patients' treatment, but also prevents high-risk family members from developing related diseases.

If more genes are detected, 7% of the risk population will not be missed.

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For a long time, doctors have realized that about 3% of colorectal cancers belong to hereditary nonpolyposis colorectal cancer (Lynch syndrome). These patients are also high-risk groups. The research leader, Matthew Yurgelun medical doctor, said that the data from the latest survey remind us that we should reduce the threshold of gene detection for colorectal cancer, because we have missed 7% of the population with genetic risk.

Sapna Syngal, M.D., said, surprisingly, we found that the frequency is higher than the previous cognition of cancer related gene mutation, which means that each colorectal cancer patients should enhance the consciousness of genetic testing, doctors should also advise patients, because it not only impact for patients, and also important for other family members.

It has long been recognized that genetic factors tend to increase the risk of cancer. People often determine whether genetic testing should be conducted to diagnose genetic syndrome through family history or the diagnosis of young diseases.

The study carried out a more extensive genetic survey, using commercialized detection of panel to find genetic mutations associated with the risk of genetic cancer. The blood samples of 1058 patients with colorectal cancer who received routine clinical care were analyzed by investigators. No samples were selected based on family history before the analysis. All samples were random and agreed with the patients.

The survey found that the incidence of genetic cancer susceptible gene mutations was 10%, 7% higher than the traditional one. Investigators said they would further study the role of the susceptibility gene mutation found in colorectal cancer, including the analysis of colorectal tumors to determine how mutations affect the development of the disease.

If more genes are tested, care can be improved after treatment.

To date, there has not been any treatment for colorectal cancer targeting tumor susceptibility genes. However, researchers speculate that other cancers' susceptible gene targeting drugs may eventually be effective for colorectal cancer. More extensive genetic testing can improve treatment after treatment.

Dr. Syngal said that if there is a mutation in the gene that allows the patient not only to have a higher risk of colorectal cancer, but also to have a higher risk of pancreatic cancer or breast cancer, we need to track these cancers later. In the same way, family members carrying genetic mutations not only regularly screen colorectal cancer, but also screen other cancers associated with mutations.

Finally, he also appealed for the time to raise awareness of gene detection in colorectal cancer patients and detect other cancers, such as breast and ovarian cancer. Although millions of people are suffering from Lynch's syndrome, most people do not know that they have this kind of gene mutation.

If more genes are detected, it must be adopted correctly.

JAMA also released the results of cancer gene detection recently. It was found that 2/3 of 2500 breast cancer patients wanted genetic testing, but in fact, less than 30% of the patients could get the test. Both JAMA and JCO surveys show that the prevalence of gene detection in cancer patients is not in place.

When considering gene testing, be sure to communicate with the doctor more and listen to the doctor's advice. Genetic counseling is also important for genetic testing.