The liver is has a variety of physiological functions in the human body organs, the lesions can cause liver dysfunction in different degrees, the general clinical examination is commonly used for bilirubin synthesis function and metabolic function examination, in addition in the liver transaminase of various biochemical metabolic enzymes can reflect the normal physiological function of liver cells and so on liver the function of inspection is very important.

bilirubin

Bilirubin from aging erythrocyte hemoglobin is liposoluble. After being treated by liver, it can be degraded and converted to a water-soluble substance that can combine with glucuronic acid and excreted in vitro.

Under the condition of liver damage, this metabolic function is damaged, resulting in the increase of serum bilirubin and the occurrence of jaundice. Therefore, the degree of liver damage is often reflected by bilirubin examination. The main way is to detect direct bilirubin and serum total bilirubin.

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Serum total bile acid (TBA)

Is a group of metabolic product of cholesterol in the liver in the enterohepatic circulation and decomposition, is the final product of cholesterol metabolism, is the main component of bile, bile acids, total bile proved solid 50%~70%, its basic structure is perhydrocyclopentanophenanthrene.

TBA is a kind of endogenous organic ions in the body divided into primary bile acids and secondary bile acids two, primary bile acids in the liver cells with cholesterol as raw materials in the digestion and absorption of fat, through the duodenal hydrolysis reaction occurred after the formation of secondary bile acids, after intestinal absorption of bile acids into the heart of the liver the biliary system into the duodenum, the whole process consists of bile acid enterohepatic circulation.

In the event of liver damage cases, serum TBA will be increased, so the bile acid metabolism affected by cholesterol metabolism, metabolism and hepatic bile acid formation and the relationship more closely, when liver injury and cholestasis cases, serum total bile acid level increased, so the serum TBA the determination of liver parenchyma can reflect the extent of damage to a certain extent.

Serum total cholesterol

The synthesis, transport and degradation, metabolism of lipids is the place of the liver, the data show that the liver is an important place for cholesterol degradation and synthesis, in the face of liver cell damage, cholesterol content for HMG auxiliary enzyme A (HMG-CoA) reductase activity decreased and lecithin cholesterol acyltransferase (LCAT) synthesis decrease, so that the determination of serum total cholesterol is reflected in liver function tests, liver synthesis and sensitive index.

Studies have shown that the serum cholesterol level of patients with chronic liver failure is significantly lower than that of patients with chronic or acute liver failure. The pathogenesis of chronic liver failure is cirrhosis, while the incidence of acute exacerbation of chronic liver failure is based on the acute attack of chronic hepatitis.

Studies have shown that the serum total cholesterol level of patients with liver failure is significantly higher than that of the death group, and the effect of serum total cholesterol on the liver function and recovery of patients with liver failure is confirmed.

With 19 high purity albumin negative charge, affected by various factors, physiological factors of diet, obesity, smoking, age, hypertension, is of great significance to the body of bilirubin, hormones, fatty acids, ion transport, and have strong affinity for inorganic compounds and organic compounds, is the hospital routine biochemistry the inspection items, is one of the important index to evaluate the liver function and prognosis in patients with liver cirrhosis.

Cirrhosis is formed by a cause of repeated action and a variety of diffuse liver injury is a common clinical chronic, progressive liver disease, mainly for the high pressure of portal vein and liver function damage, accompanied by hepatorenal syndrome, secondary infection, hepatic encephalopathy, gastrointestinal bleeding and other complications. Viral hepatitis such as hepatitis B and hepatitis C is a major risk factor for cirrhosis. Meanwhile, long-term damage such as drug, nutrition, cholestasis, fatty liver disease and alcoholic liver disease can also lead to cirrhosis.

Cirrhosis is formed by the further development of liver fibrosis, is the final pathological stage of chronic liver injury, hepatitis B virus and hepatitis C virus infection is the most common risk factors of cirrhosis, chronic inflammation in liver injury and a variety of reasons, tissue repair is the deposition of extracellular matrix, collagen and extracellular the matrix synthesis of the main component of the increased deposition of extracellular matrix degradation is relatively inadequate, resulting in liver cell dysfunction, eventually leading to the reconstruction of hepatic lobules, pseudolobule and regenerative nodules.

Of the three lesions repeatedly alternate, leading to liver cirrhosis, liver cirrhosis harden, divided into advanced cirrhosis and early cirrhosis, end-stage liver cirrhosis mainly for chronic liver failure, portal hypertension, liver dysfunction, early cirrhosis has no obvious symptoms or no symptoms in some incentives under the action of chronic liver failure for acute liver failure, there may be severe liver failure or hepatic encephalopathy.